新型N-杂环卡宾咪唑盐的合成、表征与抑菌活性研究

Synthesis, Characterization and Antibacterial Activity of Novel N-heterocyclic Carbine Imidazole Salts

以喹哪啶作为桥联基团,合成了五个新型N-杂环卡宾咪唑六氟磷酸盐化合物(5a^5e),其结构经1H NMR,13C NMR表征,用X-ray单晶衍射确定5b、5c和5e的晶体结构。单晶结构分析表明,晶体5b和5c均为三斜晶系、■空间群;5e晶体为单斜晶系、Cc空间群。5b的晶胞参数:a=6.945 1(10)nm,b=12.016 6(18) nm,c=14.791(2) nm,α=91.997(11)°,β=95.340(12)°,γ=105.845(8)°;5c的晶胞参数:a=9.975(3) nm,b=11.056(4) nm,c=12.382(4) nm,α=99.010(4)°,β=103.527(3)°,γ=112.734(3)°;5e的晶胞参数:a=18.058 9(18) nm,b=12.510 0(9) nm,c=13.365 9(12) nm,α=90.00°,β=124.522(7)°,γ=90.00°。抑菌实验结果表明,5a^5e对金黄色葡萄球菌和大肠杆菌有一定的抑制作用。

The five novel N-heterocyclic carbine imidazole hexafluorophosphate(5 a-5 e) were synthesized by choosing quinaldine as bridging group.The structures were characterized by 1H NMR and 13C NMR, and crystal structures of 5 b, 5 c and 5 e were determined by X-ray single crystal diffraction. The single crystal X-ray diffraction analysis reveals that crystals of 5 b and 5 c both belong to ■ group with the triclinic system, crystal of 5 e belongs to Cc space group with monoclinic system, the cell parameters of 5 b is a=6.945 1(10)nm, b=12.016 6(18) nm, c=14.791(2) nm, α=91.997(11)°, β=95.340(12)°, γ=105.845(8)°, the cell parameters of 5 c is a=9.975(3) nm, b=11.056(4)nm, c=12.382(4) nm, α=99.010(4)°, β=103.527(3)°, γ=112.734(3)°. The cell parameters of 5 e is: a=18.058 9(18) nm, b=12.510 0(9) nm, c=13.365 9(12) nm, α=90.00°, β=124.522(7)°, γ=90.00°. The results of bacteriostatic experiments reveal that 5 a-5 e could show certain bacteriostatic effect on S. aureus and E.coli.