难治性抑郁症定义的研究进展

Advances in the definition of treatment-resistant depression

难治性抑郁症(TRD)较为常规,但目前尚没有一个完全公认的定义。不同定义间的差异主要在具体规定上,其核心观点一致,即对于一种或几种充分的抗抑郁治疗缺乏满意的疗效,最常用的是既往两次足量、足疗程治疗无效。目前使用较多的定义方法是治疗无效法和分期模型法。现对于TRD的概念和目前用于定义TRD的不同方法及其存在的不足进行综述,以便更好地理解TRD。

Refractory depression(TRD)is widespread,but there is no fully accepted definition of TRD.The difference of definitions is mainly in the specific provisions,the core point of view is the same,that is,it is lack of satisfactory effect for one or several adequate antidepressant treatments.At present,the most commonly used definition methods for TRD is two ineffective full dose and full course treatment.This review summarizes the concept of TRD,the different methods used to define TRD and their shortcomings in order to better understand TRD.