重视帕金森病的认知障碍

Pay attention to cognitive impairment in Parkinson′s disease

认知障碍是帕金森病最常见的非运动症状之一,主要与相关脑区异常蛋白沉积、突触功能受损、多种递质系统紊乱和神经免疫异常有关。该症状在帕金森病中的发生率相对较高,严重影响着患者的生活质量,对社会和家庭造成沉重负担。目前脑脊液、外周体液、基因和神经影像学上有一些早期诊断标志物,可用于帕金森病认知障碍的预警和早期识别。对帕金森病认知障碍应重视预警和早期诊断,必要时可进行一定的干预治疗,同时有关帕金森病认知障碍的前瞻性、多中心、大样本的高质量临床研究亟待加强。

Cognitive impairment is one of the most common non-motor symptoms of Parkinson′s disease,which is mainly related to abnormal protein deposition in related brain regions,impaired synaptic function,various transmitter system disorders and neuroimmune abnormalities.The incidence of Parkinson′s disease is relatively high,which seriously affects the quality of life of patients and imposes a heavy burden on society and families.At present,there are some early diagnostic markers in cerebrospinal fluid,peripheral fluid,gene and neuroimaging,which can be used for early warning and early recognition of cognitive impairment in Parkinson′s disease.Early warning and early diagnosis of cognitive impairment in Parkinson′s disease should be emphasized,and certain intervention and treatment can be carried out if necessary.Meanwhile,prospective,multicenter and large-sample high-quality clinical studies on cognitive impairment in Parkinson′s disease are needed urgently.