帕金森病再现性震颤的机制探讨

Mechanism of re-emergent tremor in Parkinson′s disease

帕金森病是常见的中枢神经系统退行性变性病,主要原因是黑质致密部多巴胺能神经元的变性死亡。震颤是帕金森病最常见的症状之一,临床发现部分帕金森病患者改变姿势体位时会引起震颤暂时消失一段时间,之后震颤再次重新出现。这种临床现象被称为帕金森病的再现性震颤(re-emergent tremor, RET)。目前RET的原因机制尚且不清,国内外对其研究较少,因此,我们对帕金森病RET的可能机制、临床特点及意义予以综述。

Parkinson′s disease is a common degenerative disease of the central nerve system,mainly caused by the degeneration of dopaminergic neurons in the compact part of substantia nigra.Tremor is one of the most common symptoms of Parkinson′s disease.Part of patients changing posture position could cause the tremor suspended for a period of time,after that,the tremor appear again.This clinical phenomenon is characterized by the reproducibility of Parkinson′s disease tremor,called re-emergent tremor(RET).The cause of RET mechanism is still unclear and the relative researches are less.This review summarizes the possible mechanism,clinical features and significance of RET in Parkinson′s disease.