大气污染对慢性阻塞性肺疾病表观遗传学影响的研究进展

Research progress on epigenetic effects of air pollution on chronic obstructive pulmonary disease

慢性阻塞性肺疾病(COPD)是一种常见的慢性呼吸系统疾病,具有发病率及病死率高、经济负担重等特点。大气污染不仅是COPD的潜在危险因素,还是导致其急性发作、住院率及病死率增加的主要非感染因素,但具体的分子机制尚不明确。现从表观遗传学的角度就大气污染对COPD的影响机制进行综述。

Chronic obstructive pulmonary disease(COPD)is a common chronic respiratory disease with high morbidity and mortality and heavy economic burden.Air pollution is not only a potential risk factor for COPD,but also a major non-infectious factor leading to the increase in acute exacerbation,hospitalization and mortality.However,the specific molecular mechanism is still unclear.This paper reviews the mechanism of air pollution on COPD from the perspective of epigenetics.