不同年龄类风湿关节炎患者疲乏与生活质量的相关性研究

Correlation between fatigue and quality of life in patients with rheumatoid arthritis of different ages

目的调查不同年龄段类风湿关节炎(RA)患者的疲乏症状和生活质量状况,并分析其相关性。方法采用便利抽样选取2019年1—4月北部战区总医院风湿免疫科收治的200例RA患者,男29例,女171例,年龄(58.07±14.35)岁,年龄范围为19~86岁,根据WHO对于年龄的划分可分为青年组(n=36)、中年组(n=59)与老年组(n=105)。采用Bristol类风湿关节炎患者疲乏多维问卷评估其疲乏水平,采用健康调查12条简表评估其生活质量。结果三组患者疲乏总分及各维度得分比较,差异有统计学意义(P<0.05);生理健康总测量因子(PCS)总分和心理健康总测量因子(MCS)总分及总体健康、生理功能、生理职能和社会功能维度比较,差异有统计学意义(P<0.05),而躯体疼痛、情感职能、精神健康和精力维度比较,差异无统计学意义(P>0.05);疲乏得分与生活质量得分呈负相关(P<0.01)。疲乏可解释躯体健康的48.9%(F=189.632,P<0.01),疲乏可解释心理健康的65.9%(F=381.802,P<0.01)。结论不同年龄组患者疲乏和生活质量不同,二者呈负相关关系,疲乏得分越高,生活质量得分越低。

Objective To investigate the fatigue and quality of life of patients with rheumatoid arthritis(RA)of different ages,and to analyze their correlation.Methods A total of 200 RA patients,29 males and 171 females,aged from(58.07±14.35)years old and ranging from 19 to 86 years old,were selected from the convenience sampling in the Department of Traditional Chinese Medicine Rheumatism and Immunology,General Hospital of Northern Theater Command,from January to April 2019.According to WHO′s classification of age,patients can be divided into the youth group(n=36),the middle-aged group(n=59)and the elderly group(n=105).Fatigue level of patients with rheumatoid arthritis was evaluated by Bristol rheumatoid arthritis fatigue multi-dimensional questionnaire,and their quality of life was evaluated by medical outcomes study 12-item short-form health survey.Results The total fatigue scores and scores of each dimension of the three groups were compared,and the difference was statistically significant(P<0.05).The differences between physical component summary(PCS)score and mental component summary(MCS)score and the dimensions of overall health,physiological function,physiological function and social function were statistically significant(P<0.05),while there was no statistically significant difference between physical pain,emotional function,mental health and energy dimensions(P<0.05).Fatigue scores were negatively correlated with quality of life scores(P<0.01).Fatigue accounts for 48.9%of physical health(F=189.632,P<0.01),fatigue accounted for 65.9%of mental health(F=381.802,P<0.01).Conclusion Fatigue and quality of life are different in different age groups,and they are negatively correlated.The higher the score of fatigue,the lower the score of quality of life.