糖皮质激素治疗小儿重症肺炎支原体肺炎分析

Analysis of Glucocorticoid in the Treatment of Mycoplasma Pneumoniae Pneumonia in Children

目的分析阿奇霉素联合糖皮质激素治疗小儿重症支原体肺炎的临床效果。方法将我院2019年1月—2020年1月收治的92例重症肺炎支原体肺炎患儿随机分为对照组与观察组各46例,对照组患儿仅采用阿奇霉素开展治疗,观察组患儿应用阿奇霉素联合糖皮质激素治疗,分别将两组患儿的治疗效果及炎性因子水平进行统计学比较。结果观察组患儿的发热与咳嗽消退时间明显短于对照组,住院时间明显短于对照组,且临床有效率显著高于对照组,具有统计学意义(P<0.05)。同时,观察组患儿治疗后的C反应蛋白、肿瘤坏死因子-α与白介素-8水平均明显低于对照组,具有统计学意义(P<0.05)。结论采用阿奇霉素联合糖皮质激素治疗小儿重症肺炎支原体肺炎能够迅速改善患儿症状,缓解患儿全身炎症反应,对提高临床疗效有确切作用。

Objective To analyze the clinical effect of azithromycin combined with glucocorticoid in the treatment of severe mycoplasma pneumonia in children.Methods 92 children with severe mycoplasma pneumoniae pneumonia in our hospital from January 2019 to January 2020 were randomly divided into the control group and the observation group,46 cases in each group.The control group was only treated with azithromycin.The observation group was treated with Azithromycin combined with glucocorticoid.The therapeutic effect and inflammatory factor level of the two groups were compared statistically.Results The fever and cough subside time of the observation group was significantly shorter than that of the control group,the hospitalization time was significantly shorter than that of the control group,and the clinical efficiency was significantly higher than that of the control group(P<0.05).At the same time,the C-reactive protein,TNF-α and IL-8 water in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Azithromycin combined with glucocorticoid in the treatment of children with severe mycoplasma pneumoniae pneumonia can rapidly improve the symptoms of children,alleviate the systemic inflammatory response of children,and improve the clinical effect.