免疫球蛋白联合激素及吗替麦考酚酸酯治疗ITP的临床分析

Clinical Analysis of the Treatment of ITP With Immunoglobulin Combined With Hormone and Mycophenolate Mofetil

目的评价减低剂量人血免疫球蛋白联合激素及吗替麦考酚酸酯治疗原发免疫性血小板减少症的有效性及安全性。方法54例初治原发免疫性血小板减少症患者,随机分为研究组和对照组。比较两组治疗后血小板计数,完全反应率和总有效率,观察药物不良反应。结果治疗4周后,研究组的完全反应率及总有效率均高于对照组(P<0.05)。研究组起效时间低于对照组(P<0.05)。两组患者不良反应经对症处理后均可恢复正常。结论与单纯激素比较,减低剂量人血免疫球蛋白联合激素及吗替麦考酚酸酯治疗初治ITP有效率更高,起效快速,安全性较好。

Objective To evaluate the efficacy and safety of reduced dose human immunoglobulin combined with hormone and mycophenolate mofetil in the treatment of primary immune thrombocytopenia.Methods 54 patients with primary immune thrombocytopenia were randomly divided into study group and control group.The platelet count,complete response rate and total effective rate were compared between the two groups,and adverse drug reactions were observed.Results After 4 weeks of treatment,the complete response rate and total effective rate in the study group were higher than those in the control group(P<0.05).The effective time of the study group was lower than that of the control group(P<0.05).After symptomatic treatment,the adverse reactions of the two groups could return to normal.Conclusion compared with hormone alone,the treatment of ITP with reduced dose of human immunoglobulin combined with hormone and mycophenolate mofetil is more effective,rapid and safe.