巨噬细胞在慢性鼻窦炎伴鼻息肉中的研究进展

Advances in the study of macrophages in chronic rhinosinusitis with nasal polyps

慢性鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)是鼻和鼻窦黏膜的慢性炎症反应,其发病机制至今还不清楚.与其他内在型相比,Th2型CRSwNP患者常规治疗后更容易复发,鼻黏膜内金黄色葡萄球菌的定植数多,金黄色葡萄球菌感染诱导Th2炎症反应,进一步加重炎症反应.巨噬细胞在病原微生物清除方面发挥了重要作用,但在Th2失调的炎症环境下巨噬细胞吞噬和杀菌能力明显下降,可能与Th2型CRSwNP患者黏膜内金葡菌持续性存在密切相关.本文就巨噬细胞的亚型、分化和功能进行综述,寄希望于巨噬细胞的研究能有效减少病原菌定植,控制鼻黏膜内持续性炎症反应.

Chronic rhinosinusitis with nasal polyps(CRSwNP)is a chronic inflammation of nasal and sinus mucosa,and its pathogenesis is still unclear.Th2 type CRSwNP patients,with more intra-mucosal colonization of Staphylococcus aureus(S.aureus),have high recurrence rate after sinus surgery in comparison to other endotypes.Macrophages play an important role in clearance of pathogenic microorganisms.The phagocytic and bactericidal abilities of macrophages are signifiesntly decreased in Th2 inflammatory environment,leading to the persistence of S.aureus.In this review paper,we will summary the subtype,differentiation and function of macrophages.Finding effective ways to restore the functio n of deficit macrophages by some relative researches in CRSwNP may reduce the colonization of pathogenic bacteria and control the persistent inflammatory response of mucosa.