VEGF及其靶向药物的研究进展

Advances in VEGF and its targeted drugs

肿瘤的生长转移和新血管的生成密切相关,许多调节血管生成的细胞因子参与血管的生成,而在肿瘤血管生成中起关键作用的是血管内皮细胞生长因子(vascular endothelial growth factor, VEGF)及其信号通路。阻断该通路的任何环节都会有效抑制肿瘤血管的生成,进而抑制肿瘤的生长和转移。基于VEGF的调控特点,很多以VEGF及其受体VEGFR为靶点的抗肿瘤血管生成药物已经问世。本文主要概述抗VEGF的靶向药物治疗及特点。

Tumor growth and metastasis depend on angiogenesis that is taken part in by lots of cytokines, and vascular endothelial growth factor(VEGF) and its signaling pathway play a key role in tumor-associated angiogenesis. Blocking any step in this pathway can effectively inhibit the tumor-associated angiogenesis and thereby inhibit the growth and metastasis of tumor. Many anti-tumor angiogenesis drugs targeting VEGF and its receptor VEGFR have been marketed based on the characteristics of VEGF regulation. The anti-VEGF targeted drug therapy and its characteristics are mainly summarized in this article.