摘要
目的评价板蓝根颗粒联合布地奈德气雾剂治疗慢性咽炎的临床疗效及安全性。方法选取我院2017年9月~2018年5月收治的80例慢性咽炎患者为研究对象,采用随机分组的方法分为治疗组和对照组各40例。对照组吸入布地奈德气雾剂,初始剂量为0.5 mg/次,3次/d;治疗组在对照组基础上再口服板蓝根颗粒,1袋/次,3次/d,两组患者连续治疗2周。比较两组患者治疗前后的临床疗效、中医证候疗效、炎性因子水平及安全性指标。结果治疗组总有效率为92.11%,对照组总有效率为64.86%,两组比较差异有统计学意义(P<0.05);治疗组中医证候疗效总有效率94.74%,对照组为56.76%,治疗组在改善咽干、咽痒、大便干燥、小便赤黄、咽后壁淋巴滤泡增生、咽后壁血管扩张等症状方面优于对照组(P<0.01);治疗组能有效降低中性粒细胞和嗜酸性粒细胞水平,显著优于对照组(P<0.05);临床观察期间患者无不良反应发生。结论板蓝根颗粒联合布地奈德气雾剂治疗慢性咽炎具有较好的疗效及较高的安全性,能有效降低患者炎性因子水平,具有较好的临床推广应用价值。
Objective To evaluate the clinical efficacy and safety of isatis-root granules combined with budesonide aerosol in the treatment of chronic pharyngitis.Methods 80 patients with chronic pharyngitis admitted to our hospital from September 2017 to May 2018 were selected as the subjects of research,and were randomly divided into two groups with 40 patients in each group.The control group inhaled budesonide aerosol with an initial dose of 0.5 mg tid.For the treatment group,isatis-root granules were added to the prescription for the control group,and were taken orally 1 bag tid.In such ways the two groups of patients were treated continuously for 2 weeks.The clinical efficacy,TCM syndrome efficacy,inflammatory factor level and safety indexes of the patients before and after treatment were compared.Results The total effective rate of the treatment group was 92.11%,while that of the control group was 64.86%,and the difference between the data of the two groups was significant(P<0.05).The total effective rate of TCM syndrome efficacy of the treatment group was 94.74%,while that of the control group was 56.76%,and the treatment group had significant advantages in ameliorating symptoms such as pharyngeal dryness,pharyngeal itching,dry stool,deep-colored urine,hyperplasia of lymphoid follicles in posterior pharyngeal wall,vasodilation of posterior pharyngeal wall,etc.(P<0.01).The levels of neutrophils and eosinophils in the treatment group were reduced effectively and were significantly lower than those in the treatment group(P<0.05).No adverse reactions(ADRs)occurred to the patients during clinical observation1.Conclusion Isatis-root granules combined with budesonide aerosol has better efficacy and sounder safety in the treatment of chronic pharyngitis.It can reduce the inflammatory factor level effectively for the patients.It is of great value for clinical promotion and application.
作者
黄虹芝
王旭
HUANG Hongzhi;WANG Xu(The First School of Clinical Medicine,Nanjing University of Chinese Medicine,Nanjing210023,China;The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing210029,China)
出处
《中国现代医生》
2020年第18期143-147,共5页
China Modern Doctor
关键词
板蓝根颗粒
布地奈德气雾剂
慢性咽炎
临床观察
Isatis-root granules
Budesonide aerosol
Chronic pharyngitis
Clinical observation