脂肪酸结合蛋白与糖尿病血管病变的研究进展

Research progress on fatty acid binding protein and diabetic vasculopathy

糖尿病在全球的患病率日益增加,糖尿病血管并发症是目前老龄人群中致死和致残的首要原因。脂肪酸结合蛋白(FABP)是一类脂质伴侣家族,是联结肥胖、糖尿病与血管疾病的关键炎症分子,在糖尿病血管病变中发挥重要作用。本文对FABP家族成员在糖尿病及其血管病变发生发展中的分子机制、作为干预靶点的治疗价值以及成为生物标志物的临床意义进行综述,以期为以FABP为代表的抗糖尿病血管病变的药物研发提供证据与思路。

The prevalence of diabetes is increasing globally.Diabetic vascular complications are the primary cause of death and disability in the elderly at present.Fatty acid binding protein(FABP),a family of lipid chaperones,is a key inflammatory molecule linking obesity,diabetes and vascular diseases,and plays an important role in diabetic vasculopathy.This article reviews the molecular mechanism of FABP family members in the occurrence and development of diabetes mellitus and its vasculopathy,the therapeutic value as intervention target and the clinical significance as biomarkers,in order to provide evidence and ideas for the research and development of anti-diabetic vasculopathy drugs represented by FABP.