心脏自主神经及其重构区参与心房颤动的机制的研究进展

Advances in atrial fibrillation and cardiac autonomic nerve and its remodeling area

心房颤动(简称“房颤”)是临床工作中最常见的心律失常,约占因心律失常住院患者的1/3。有越来越多的研究显示,心脏自主神经及其重构参与了房颤的发生与维持,是房颤发生的重要机制之一。目前房颤的治疗方法包括药物治疗及射频消融术,众所周知,药物治疗存在较多的局限性,文章从交感、副交感神经与房颤发生机制及发生前后心脏自主神经重构区变化方面进行研究,探索更好的房颤治疗方式,进而简化繁琐的射频消融步骤,减小消融范围,更加精确定位异位触发点及易损基质,降低消融强度,提高手术成功率,获得良好的经济效益。

Atrial fibrillation(AF)is the most common arrhythmia in clinical work,accounting for about 1/3 of patients in hospital due to arrhythmia.Recently,more and more studies have shown that cardiac autonomic nerve and its remodeling are involved in the occurrence and maintenance of AF,which is one of the important mechanisms of AF.At present,the treatment methods of AF include drug therapy and radiofrequency ablation.As we all know,drug therapy has many limitations.In this paper,the mechanism of sympathetic,parasympathetic nerve and AF and the changes of cardiac autonomic nerve and its remodeling area before and after the occurrence of AF were studied,so as to explore a better treatment method of AF,and then simplify the tedious steps of radiofrequency ablation,reduce the scope of ablation,more accurately locate ectopic trigger point and vulnerable matrix,reduce the intensity of ablation,improve the success rate of operation and obtain good economic benefits.