40岁及以上女性人群正常参考值范围内血清TSH与骨密度的相关性研究

Study on correlation between serum TSH and bone mineral density in the normal reference ranges of women aged 40 years and above

目的研究贵阳市中、老年女性人群中正常参考范围内血清促甲状腺素(TSH)水平与骨密度之间的关系,为早发现、早诊断、早治疗骨质疏松症提供一定的参考依据。方法将所有入选研究对象根据绝经与否的不同分为A、B两组,A组为未绝经女性,B组为绝经后女性。随后再根据我院TSH检测系统给定的参考值范围(0.55≤TSH≤4.78 mIU/L),再分别将A、B两组按照3分位数等分为三组,然后应用Spearman方法比较不同正常参考范围内血清TSH水平与骨密度之间的相关性。结果无论是在A组还是B组,正常参考范围内血清TSH水平与骨密度均不存在相关关系(P>0.05)。运用Logistic回归分析提示,在A组及B组调整年龄、BMI、吸烟、饮酒后,正常参考范围内血清TSH可能并不是骨密度降低的保护因素或者危险因素(P>0.05)。结论 40岁以上女性正常范围内的血清TSH与骨密度之间并无相关关系,亦不是骨密度的保护因素或者危险因素。

Objective To study the relationship between serum TSH level and bone mineral density in the normal reference range of middle-aged and elderly women in Guiyang City,so as to provide certain reference basis for early detection,early diagnosis and early treatment of osteoporosis.Methods All subjects were divided into groups A and B according to the difference of menopause.Group A was pre-menopausal women and group B was post-menopausal women.Then according to the reference range(0.55≤TSH≤4.78 mIU/L) given by the TSH detection system of our hospital,groups A and B were divided into three groups according to the 3 quantiles,and then Spearman method was used to compare the correlation between serum TSH level and bone mineral density in different normal reference ranges.Results there was no correlation between serum TSH level and bone mineral density within the normal reference range in either group A or group B(P>0.05).Logistic regression analysis suggested that after adjusting for age,BMI,smoking and drinking in group A and group B,serum TSH within the normal reference range may not be protective factor or risk factor for bone mineral density reduction(P>0.05).Conclusion Serum TSH in the normal range is not associated with BMD in women over 40 years of age,nor was it a protective or risk factor for BMD.