PP13、PIGF、sFlt-1联合检测诊断及预测早期子痫前期价值

Value of combined detection of PP13,PIGF and sFlt-1 for predicting preeclampsia early

目的:胎盘蛋白-13(PP13)、胎盘生长因子(PIGF)、可溶性血管内皮生长因子受体-1(sFlt-1)联合检测对子痫前期早期诊断及预测价值。方法:选择2018年1月-2019年6月在本院产前检查孕妇800例进行前瞻性研究,随访孕早、中、晚期孕妇一般情况并检测各血清因子,比较子痫前期组(n=68)和非子痫前期组(n=732),以及水平变化,轻度子痫前期和重度子痫前期PP13、PIGF、sFlt-1水平,分析子痫前期发病危险因素,ROC曲线分析PP13、PIGF、sFlt-1水平变化对子痫前期早期的诊断预测价值。结果:800例孕妇中有68例(8.5%)发生子痫前期,孕早、中、晚期以及不同程度子痫前期孕妇PP13、PIGF、sFlt-1水平存在差异(均P<0.05);PP13、PIGF、sFlt-1联合检测对子痫前期疾病预测敏感性(81.01%)、特异性(86.32%)和诊断的敏感性(80.28%)、特异性(88.36%)最佳(P<0.05)。结论:PP13、PIGF、sFlt-1联合检测可较好地预测和诊断早期子痫前期及其严重程度。

Objective:To investigate the value of combined detection of the levels of placenta protein-13(PP13),placental growth factor(PIGF),and soluble vascular endothelial growth factor receptor-1(sFlt-1)for predicting and diagnosing preeclampsia early.Methods:Between January 2018 and June 2019,a prospective study was conducted in 800 pregnant women.The general situation and the serum factor changes of these women during the first,second,and third trimester of pregnancy.68 women with preeclampsia were in group A(women with mild preeclampsia in group A1 and women with severe preeclampsia in group A2),and 732 women withou preeclampsia were in group B.The levels of PP13,PIGF,sFlt-1 of women were compared between group A and group B,and the PP13,PIGF,sFlt-1 levels of women were compared between group A1 and A2.The risk factors of the preeclampsia onset were analyzed,and ROC curve was used to analyze the prediction and diagnostic value of the combination PP13,PIGF and sFlt-1 levels for early preeclampsia.Results:Among the 800 pregnant women,68(8.5%)women had developed preeclampsia during pregnancy.There were significant different in PP13,PIGF and sflt-1 levels of women with different degrees of preeclampsia during the first,second,and third trimester of pregnancy(all P<0.05).The sensitivity and the specificity of the combination detection of PP13,PIGF and sflt-1 levels for predicting preeclampsia were 81.01%and 86.32%,and the sensitivity and the specificity of the combination of PP13,PIGF and sflt-1 levels for diagnosing preeclampsia were 80.28%and 88.36%,which were the best.Conclusion:The combination detection of PP13,PIGF and sflt-1 levels can further improve the accuracy of predicting and diagnosing preeclampsia and the severity degree of preeclampsia.