曲安奈德在葡萄膜炎并发白内障治疗中的效果研究

Triamcinolone in the Treatment of Uveitis with Cataract

目的探讨对葡萄膜炎并发白内障患者术后采用曲安奈德治疗的临床效果。方法抽取2018年10月—2019年10月在该院接受治疗的葡萄膜炎并发白内障术后患者78例,按照等差数列首项为1,公差为7的方式将78例患者平均分为两组,即对照组与实验组,每组患者均为39例。对照组采用泼尼松龙治疗,实验组在泼尼松龙的基础上给予曲安奈德治疗,以两个月为治疗周期,观察两组患者的治疗效果。结果实验组患者术后1个月有92.30%患者恢复,对照组仅有74.35%,组间差异有统计学意义(χ~2=7.58,P<0.05)。实验组患者术后1 d、1周、1个月眼压分别为(19.77±2.11)mmHg、(17.36±1.76)mmHg、(14.32±1.44)mmHg,对照组为(19.97±2.01)mmHg、(18.32±1.27)mmHg、(15.88±1.27)mmHg,组间差异无统计学意义(t=0.33、0.28、0.14、0.19,P>0.05)。实验组术后1 d、1周患者为"+"概率分别为51.28%、97.43%,对照组分别为23.07%、79.48%,组间差异有统计学意义(χ~2=7.98、8.34,P<0.05)。实验组患者并发症发生几率为5.12%,对照组为20.51%,组间差异有统计学意义(χ~2=4.13,P<0.05)。结论曲安奈德在葡萄膜炎并发白内障治疗中的效果显著,能够在短时间内改善患者的视力,减轻患者的炎症,同时降低各种并发症的发生几率。

Objective To investigate the clinical effect of triamcinolone on postoperative cataract patients with uveitis.Methods Seventy-eight patients with uveitis complicated with cataract who were treated in the hospital from October 2018 to October 2019 were selected,and 78 patients were divided into two equally according to the method of the first order of the difference and 1 with a tolerance of 7.The patients were divided into two groups,namely the control group and the experimental group,had 39 patients in each group.The control group was treated with prednisolone.The experimental group was treated with triamcinolone on the basis of prednisolone.The two-month treatment cycle was used to observe the treatment effect of the two groups of patients.Results 92.30%of patients in the experimental group recovered 1 month after surgery,compared with 74.35%in the control group,and the difference was statistically significant(4.52,P<0.05).The IOP of the experimental group was(19.77±2.11)mmHg,(17.36±1.76)mmHg,(14.32±1.44)mmHg at 1 d,one week,and one month after surgery,compared with(19.97±2.01)mmHg,(18.32±1.27)mmHg,(15.88±1.27)mmHg,and the difference was not statistically significant(t=0.33,0.28,0.14,0.19,P>0.05).The probability of being“+”in the experimental group at 1 day and one week after surgery was 51.28%and 97.43%,respectively,in the control group was 23.07%and 79.48%,and the difference was statistically significant(χ2=7.92,8.34,P<0.05).The incidence of complications in the experimental group was 5.12%,compared with 20.51%in the control group,and the difference was statistically significant(χ2=4.13,P<0.05).Conclusion Triamcinoloneide has a significant effect in the treatment of uveitis complicated with cataract.It can improve the patient's vision in a short time,reduce the patient's inflammation,and reduce the incidence of various complications.