齐拉西酮治疗首发精神分裂症患者的临床疗效观察研究

Observation of Clinical Efficacy of Ziprasidone in Patients with First-onset Schizophrenia

目的探究首发精神分裂症患者采用齐拉西酮治疗的临床价值。方法由2017年10月—2019年10月该院收治的首发精神分裂症患者中选择86例作为研究对象,根据随机数字表法分成两组,各43例,对照组采用利培酮治疗,治疗组采用齐拉西酮治疗。比较两组治疗效果、不良反应发生率和生活质量。结果治疗后,治疗组总有效率97.67%高于对照组86.05%,差异有统计学意义(χ~2=3.888,P<0.05);治疗组不良反应总发生率6.98%与对照组27.91%比较,差异有统计学意义(χ~2=6.541,P<0.05);治疗组精神健康评分(87.19±10.02)分、生理功能评分(86.95±10.41)分、心理功能评分(86.33±10.08)分、社会关系评分(88.01±10.23)分与对照组(70.46±10.18)分、(71.25±10.52)分、(72.36±10.24)分、(72.59±10.87)分比较,差异有统计学意义(t=7.680,P<0.05;t=6.956,P<0.05;t=6.375,P<0.05;t=6.774,P<0.05)。结论齐拉西酮治疗首发精神分裂症安全有效。

Objective To explore the clinical value of ziprasidone treatment in patients with first-onset schizophrenia.Methods From October 2017 to October 2019,86 patients with first-onset schizophrenia were selected as the research object,and divided into two groups of 43 cases according to the random number table method.The control group was treated with risperidone.The treatment group was treated with ziprasidone.The treatment effects,incidence of adverse reactions,and quality of life were compared between the two groups.Results After treatment,the total effective rate in the treatment group was 97.67%higher than that in the control group,86.05%,which was statistically significant(χ2=3.888,P<0.05).The total incidence of adverse reactions in the treatment group was 6.98%compared with 27.91%in the control group.There was statistical significance(χ2=6.541,P<0.05);the mental health score(87.19±10.02)points,the physiological function score(86.95±10.41)points,the psychological function score(86.33±10.08)points,and the social relationship score in the treatment group(88.01±10.23)points was statistically significant compared with the control group(70.46±10.18)points,(71.25±10.52)points,(72.36±10.24)points,and(72.59±10.87)points,and the difference was statistically significant(t=7.680,P<0.05;t=6.956,P<0.05;t=6.375,P<0.05;t=6.774,P<0.05).Conclusion Ziprasidone is safe and effective in the treatment of first-onset schizophrenia and is worthy of adoption.