童年虐待对精神分裂症患者认知功能和临床症状的影响

Effects of childhood maltreatment on cognitive function and clinical symptoms in patients with schizophrenia

目的:探讨精神分裂症患者的童年虐待经历对其认知功能和临床症状的影响。方法:对46例精神分裂症患者依据儿童期虐待问卷(CTQ)评分分为轻度虐待组(27例)和重度虐待组(19例);并采用阳性和阴性症状量表(PANSS)、临床总体印象量表(CGI)及CogState量表(CSB)评估其临床症状及认知功能;分析童年虐待与认知功能和临床症状的关系。结果:重度虐待组CTQ总分及情感虐待、躯体虐待、性虐待、躯体忽视评分显著高于轻度虐待组(P均<0.01);PANSS总分、阳性因子及CGI评分明显高于轻度虐待组(P<0.05或P<0.01);CSB中的注意力及警觉高于轻度虐待组,工作记忆评分明显低于轻度虐待组(P<0.05或P<0.01)。结论:童年经历严重虐待的精神分裂症患者其精神症状更重,认知功能损害更明显。

Objective:To explore the effects of childhood maltreatment on cognitive function and clinical symptoms in patients with schizophrenia.Method:46 patients with schizophrenia were divided into mild abuse group(27 cases)and severe abuse group(19 cases)according to the scores of childhood trauma questionnaire(CTQ).Positive and negative symptom scale(PANSS)and clinical general impression scale(CGI)were used to evaluate their clinical symptoms,and Chinese vision of CogState scale(CSB)were used to evaluate their cognitive function,respectively.Results:The total CTQ scores and emotional abuse,physical abuse,sexual abuse and physical neglect scores of the severe abuse group were significantly higher than those of the mild abuse group(all P<0.01).PANSS total score,positive factor and CGI score were significantly higher than those of the mild abuse group(P<0.05 or P<0.01).The scores of attention and alertness was higher and working memory in CSB was significantly lower compared with the mild abuse group(P<0.05 or P<0.01).Conclusion:The more severe the childhood trauma experienced by patients with schizophrenia,the more severe the clinical manifestations and cognitive deficits.