液体活检在结直肠癌诊断中的应用进展

Application progress of liquid biopsy in the diagnosis of colorectal cancer

结直肠癌(Colorectal cancer,CRC)作为全球第三大常见癌症,是导致人类死亡的重要原因之一。目前针对CRC的诊断手段仍在不断完善,液体活检作为一种新兴的无创活检组织检查技术,受到广泛关注。液体活检主要对生物源液体特定成分进行分析,其中主要包括循环肿瘤细胞、循环肿瘤DNA、细胞游离DNA、外泌体、肿瘤相关血小板及循环肿瘤相关微粒等。本文就以上生物源液体特定成分在CRC诊断中的最新应用研究进行综述。

Colorectal cancer(CRC),as the third most common cancer in the world,is one of important cause of human death.At present,the diagnostic methods for CRC are still being improved.Liquid biopsy,as an emerging non-invasive biopsy technology,has attracted widespread attention.Liquid biopsy mainly analyzes specific components of biological source liquid,which mainly include circulating tumor cells,circulating tumor DNA,cell free DNA,exosomes,tumor-educated platelets,and circulating tumor-associated microparticles.This article reviews the latest application research of the above biological source liquid specific components in the diagnosis of CRC.