长链非编码RNA HOTAIR在宫颈癌中的相关研究进展

Research Progress of long-chain non-coding RNA HOTAIR and cervical cancer

长链非编码RNA(lncRNA)是一类转录长度大于200个核苷酸的非编码RNA分子,其在机体内广泛参与细胞内基因的表达与调控,调控机体的多种生理、病理过程。近年来,多项研究显示lncRNA的异常表达在肿瘤的发生发展中起着重要作用。其中,HOX转录反义RNA(HOTAIR)作为lncRNA中的一种,其表达与多个肿瘤转移密切相关,尤其在宫颈癌的迁移、侵袭、转移和复发中起着关键作用。HOTAIR可能为宫颈癌潜在的新型肿瘤标记物,因此,明确其与宫颈癌的关系及其在宫颈癌的临床诊断、治疗及预后中的作用,具有重要价值,故本文就HOTAIR与宫颈癌关系的相关研究进展做一简要综述。

Long-chain non-coding RNA(lncRNA)is a type of non-coding RNA molecule with a transcriptional length of more than 200 nucleotides.It is widely involved in the expression and regulation of intracellular genes in the body,and regulates various physiological and pathological processes of the body.In recent years,many studies have shown that the abnormal expression of lncRNA plays an important role in tumorigenesis and development.Among them,HOTAIR transcription antisense RNA(HOTAIR),as one of lncRNA,is closely related to the metastasis of multiple tumors,and plays a key role in the migration,invasion,metastasis and recurrence of cervical cancer.HOTAIR may be potential new tumor marker for cervical cancer.Therefore,it is important to clarify its relationship with cervical cancer and its significance in the clinical diagnosis,treatment and prognosis of cervical cancer.Therefore,this paper gives a brief review of related research progress of HOTAIR and cervical cancer.