胃溃疡伴胃出血行奥美拉唑、铝碳酸镁联合瑞巴派特治疗的临床研究

Clinical Study of Omeprazole,Aluminum Magnesium Carbonate Combined with Rebamipide for Gastric Ulcer with Gastric Bleeding

目的研究胃溃疡伴胃出血行奥美拉唑、铝碳酸镁联合瑞巴派特治疗的临床效果。方法将自2017年2月—2018年2月时间段该院收治的胃溃疡伴胃出血患者102例作为观察对象,通过随机抽签法将其均分为试验组和对照组,每组51例。对照组治疗方案为奥美拉唑+铝碳酸镁,试验组则在对照组治疗方案的基础上增用瑞巴派特治疗。对比两组在临床疗效,各项症状缓解时间,治疗前后血清炎症因子,不良反应等方面的差异。结果试验组治疗有效率高于对照组,且在各项症状缓解时间方面低于对照组,两组比较差异有统计学意义(P<0.05)。两组治疗后的血清白细胞介素-10(IL-10)、白细胞介素-13(IL-13)水平均分别明显较治疗前更高,且治疗后试验组(289.11±30.35)μg/L、(67.85±17.46)pg/mL较对照组也更高(t=8.323、4.921,P<0.05)。试验组与对照组在恶心呕吐、腹泻、头晕发生率方面对比,差异无统计学意义(P>0.05)。结论在奥美拉唑与铝碳酸镁治疗的基础上增用瑞巴派特可显著提高胃溃疡伴胃出血患者的临床疗效,促进患者各项症状缓解,降低炎症反应。用药安全性较佳。

Objective To study the clinical effect of omeprazole,aluminum magnesium carbonate combined with rebamipide on gastric ulcer with gastric bleeding.Methods From February 2017 to February 2018,102 patients with gastric ulcer and gastric hemorrhage admitted to the hospital were recorded as observation objects,and they were divided into a test group and a control group by random lottery example.The treatment plan of the control group was omeprazole+aluminum magnesium carbonate,and the experimental group was treated with rebamipide based on the treatment plan of the control group.Compare the differences in clinical efficacy,relief time of various symptoms,serum inflammatory factors and adverse reactions before and after treatment between the two groups.Re-sults The treatment efficiency of the experimental group was higher than that of the control group,and it was lower than that of the control group in terms of remission time of various symptoms.The difference between the two groups was statistically significant(P<0.05).The levels of serum interleukin-10(IL-10)and interleukin-13(IL-13)after treatment in the two groups were significantly high-er than before treatment,and the experimental group(289.11±30.35)μg/L after treatment,(67.85±17.46)pg/mL was also higher than the control group(t=8.323,4.921,P<0.05).Compared with the control group,the incidence of nausea,vomiting,diarrhea,and dizziness were not statistically significant difference(P>0.05).Conclusion Based on the treatment of omeprazole and aluminum magnesium carbonate,the addition of rebamipide can significantly improve the clinical efficacy of patients with gastric ulcer and gastric hemorrhage,promote the relief of various symptoms and reduce the inflammatory response.The safety of medication is better.