硝苯地平联合盐酸利托君对先兆早产母婴结局的影响

Effect of nifedipine combined with ritodrine hydrochloride on maternal and infant outcomes of threatened premature delivery

目的探讨硝苯地平联合盐酸利托君对先兆早产母婴结局的影响。方法选择解放军第71集团军医院2017年3月至2018年9月收治的94例先兆早产孕妇,按照随机表法分为对照组(47例)与观察组(47例)。对照组采用盐酸利托君治疗,观察组在对照组基础上结合治疗。比较两组治疗疗效、延长妊娠时间及保胎成功率,分析治疗前后血清炎症因子变化及母婴结局情况。结果观察组孕妇总有效率(95.74%)高于对照组(76.60%),差异具有统计学意义(P<0.05)。观察组孕妇延长妊娠时间为(21.74±3.42)d,保胎成功率(95.74%),均优于对照组,差异有统计学意义(P<0.05)。与治疗前比较,两组孕妇治疗后血清IL-2水平降低,而IL-4和IL-10水平升高,差异均有统计学意义(P<0.05);观察组孕妇血清炎症因子治疗前后的差值均高于对照组,差异均有统计学意义(P<0.05)。两组新生儿的出生窒息、低体质量儿发生率及围产儿死亡率的差异无统计学意义(P>0.05)。结论硝苯地平联合盐酸利托君对先兆早产孕妇疗效良好,母婴结局良好,值得临床借鉴。

Objective To investigate the effect of nifedipine combined with ritodrine hydrochloride on the outcome of threatened premature delivery.Methods A total of 94 expectant mothers with preterm birth admitted to the 71st Group Military Hospital of the PLA from March 2017 to September 2018 were selected as the study subjects.According to the random table method,they were divided into two groups,with 47 cases in control group and 47 cases in observation group.The control group was treated with ritodrine hydrochloride,while the observation group was treated with nifedipine on the basis of the control group.The therapeutic effects,prolonged pregnancy time and successful rate of fetal protection,changes of serum inflammatory factors before and after treatment,and maternal and infant outcomes were compared between the two groups.Results The total effective rate of pregnant women in observation group(95.74%)was higher than that in control group(76.60%)with statistically significant difference(P<0.05).The pregnant women inobservation group extended their gestation time for(21.74±3.42)d,and the success rate of fetal protection was(95.74%),both of which were better than those of control group,and the differences were statistically significant(P<0.05).Compared with those before treatment,serum IL-2 levels of pregnant women in two groups decreased after treatment,while IL-4 and IL-10 levels increased,with statistically significant differences(P<0.05).The difference in serum inflammatory factors before and after treatment in observation group was higher than that in control group,and the difference was statistically significant(P<0.05).There was no significant difference in birth asphyxia,low body mass index and perinatal mortality between the two groups(P>0.05).Conclusions Nifedipine combined with ritodrine hydrochloride has a good effect on threatened preterm pregnant women and good maternal and infant outcomes,which is worthy of clinical reference.