残余炎性心血管风险的研究进展

Progress of residual inflammatory cardiovascular risk

冠状动脉疾病是导致人类发病和死亡的重要原因。虽然近年来对心血管疾病危险因素的综合控制取得了显著成效,然而在低密度脂蛋白胆固醇、血压、血糖等传统危险因素控制达标后,心血管事件发生率仍然较高,统称为心血管残余风险。炎症是动脉粥样硬化形成和斑块破裂的核心驱动因素,是心血管残余风险的重要原因。文章主要就残余炎性心血管风险的形成、评估以及针对残余炎性风险的治疗等方面进行综述。

Coronary artery disease(CAD)remains a leading cause of morbidity and mortality in the world.Although the comprehensive control of cardiovascular disease risk factors has achieved remarkable progress in recent years,the incidence of cardiovascular events is still high after the control of traditional risk factors such as low density lipoprotein cholesterol,blood pressure and blood glucose,collectively referred to as cardiovascular residual risk.Inflammation is a central driver of atherosclerosis and the ultimate rupture of plaque,as well as an important cause of residual cardiovascular risk.Therefore,this article reviews the formation,assessment and treatment of residual inflammatory cardiovascular risk.