创伤性脑损伤预后相关生物标志物的研究进展

Advances in prognostic related biomarkers of traumatic brain injury

创伤性脑损伤(TBI)是一种发生率、致残率和致死率较高的临床急症,给患者、家庭及社会带来严重的影响。TBI预后相关生物标志物一定程度上不仅可以反映机体损伤的发生机制和病理生理过程,而且在评估损伤严重程度、预测不良结局、制定治疗决策等方面具有重要价值。文章拟对TBI预后相关的凝血、炎症、神经系统损伤等生物标志物的研究进展作一综述。

Traumatic brain injury(TBI)is a kind of clinical emergency with high incidence,disability and mortality,with serious impact on patients,families and society.To some extent,prognostic related biomarkers of TBI can not only reflect the pathogenetic mechanism and pathophysiological process of injury,but also have important values in evaluating the severity,predicting adverse outcomes,making treatment decisions and so on.This article aims to review the studies about the prognosis biomarkers of TBI,such as coagulation related biomarkers,inflammation related biomarkers,biomarkers related to nervous system injury and so on.