普洱茶中没食子酸及其改善饮食诱导的糖脂代谢紊乱研究进展

Research Progress of Gallic Acid in Puer Tea and Its Improvement of Diet Induced Glucose and Lipid Metabolism Disorder

糖脂代谢紊乱是引发心血管疾病、糖尿病和脂肪肝的重要原因之一。普洱茶中的没食子酸能够通过调节能量代谢和脂肪细胞分化、促进葡萄糖吸收与利用、提高胰岛素敏感性,进而改善饮食诱导引起的葡萄糖和脂质代谢紊乱。没食子酸通过AMPK途径、IR-Akt途径以及PPAR-γ受体调节线粒体能量代谢、胰岛素敏感性和葡萄糖吸收,从而维持糖脂代谢稳态。本文综述了普洱茶中的没食子酸及其改善饮食诱导的糖脂代谢紊乱作用和作用机制的研究进展。

The disorder of glucose and lipid metabolism is one of the important causes of cardiovascular diseases,diabetes and fatty liver.Gallic acid of Puer tea can ameliorate diet induced glucose and lipid metabolism disorder through regulating energy metabolism and adipocyte differentiation,promoting glucose absorption and utilization,and increasing insulin sensitivity.Gallic acid regulates mitochondrial energy metabolism,insulin sensitivity and glucose absorption to maintain glucose and lipid metabolism homeostasis through AMPK and IR-Akt pathway and PPAR gamma receptor.In this review,we summarized gallic acid in Puer tea and its mechanism to improve the disorder of glucose and lipid metabolism induced by diet.