不同年龄段脓毒血症患者血液检测指标的差异及原因分析

Analysis of differences and causes of blood test indices in sepsis patients of different ages

目的:探讨不同年龄段脓毒血症患者血液检测指标的差异并分析原因,为临床对脓毒血症患者的诊断提供依据。方法:选取2016-12—2018-11收治的脓毒血症患者88例为研究对象,按年龄分为A组(<40岁,n=20)、B组(40~60岁,n=30)和C组(>60岁,n=38)。检测并分析3组患者血清D-二聚体(D-D)、C-反应蛋白(CRP)、血小板(PLT)、凝血酶原时间(PT)、部分活化凝血活酶时间(APTT)、白细胞(WBC)、降钙素原(PCT)、淋巴细胞的差异。结果:脓毒血症患者的D-D、PLT、PT、APTT、WBC、CRP、PCT均随着年龄增长而升高(P>0.05),而淋巴细胞随着年龄增长而减少(P>0.05),且年龄与D-D、PLT、PT、APTT、WBC及PCT呈正相关(P<0.05),淋巴细胞与年龄呈负相关(P<0.05),年龄与CRP无相关性(P>0.05)。结论:不同年龄段脓毒血症患者血液检测指标存在一定差异,如D-D、PLT、PT、APTT、WBC、PCT等会随着年龄增长而升高,且呈正相关;而淋巴细胞随着年龄增长而减少,且呈负相关。因此临床可根据患者年龄阶段判断相关血液检测指标变化与疾病的关系。

Objective:To explore the differences of blood test indexes in sepsis patients of different ages and analyze the causes,so as to provide basis for clinical diagnosis of sepsis patients. Method:Eighty-eight patients with sepsis admitted to our hospital from December 2016 to November 2018 were selected as the study subjects.They were divided into group A(<40 years old,n=20),group B(40-60 years old,n=30)and group C(>60 years old,n=38)according to their age.The serum D-dimer,CRP,PLT,PT,APTT,WBC,PCT and lymphocyte were detected and analyzed. Result:D-dimer,PLT,PT,APTT,WBC,CRP and PCT increased with age(P>0.05),while lymphocyte decreased with age(P>0.05).Age was positively correlated with D-dimer,PLT,PT,APTT,WBC and PCT(P<0.05),and lymphocyte was negatively correlated with age(P<0.05).There was no correlation(P>0.05).Conclusion:There are some differences in blood detection indicators in sepsis patients of different age groups,such as D-dimer,PLT,PT,APTT,WBC,PCT,etc.would increase with age,and there is a positive correlation,while lymphocyte decreases with age,and there is a negative correlation.Therefore,we can judge the relationship between the changes of related blood indicators and diseases according to the age of patients,and pay more attention to the changes of related blood indicators in elderly patients with sepsis.