针灸联合中药治疗卵巢癌恶性腹腔积液临床观察

Clinical Observation of Acupuncture-moxibustion Combined with Chinese Medication for Malignant Ascites in Ovarian Cancer

目的观察针灸联合中药治疗卵巢癌恶性腹腔积液的临床疗效及对腹腔积液、Karnofsky功能状态评分(KPS)的影响。方法选取卵巢癌恶性腹腔积液患者62例,依随机数字表法分为观察组和对照组,每组31例。所有患者均进行腹腔灌注化疗,对照组采取中药(六味地黄丸+六君子汤+己椒苈黄丸加减)治疗,观察组在对照组基础上联合针灸治疗,均治疗1个月。对比分析两组临床疗效及腹腔积液引流次数、KPS评分变化及不良反应发生情况。结果观察组总有效率高于对照组(P<0.05);观察组引流腹腔积液次数少于对照组,差异有统计学意义(P<0.05);两组治疗前临床症状综合评分比较差异无统计学意义(P>0.05),治疗后两组临床症状综合评分比治疗前均有下降(P<0.05),且观察组治疗后低于对照组(P<0.05);两组治疗前KPS评分比较差异无统计学意义(P>0.05),两组治疗后KPS评分比治疗前均有上升(P<0.05),且观察组治疗后KPS评分高于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05)。结论针灸联合中药治疗卵巢癌恶性腹腔积液的疗效明显,可改善患者的临床症状并降低腹腔积液引流次数,提高其生活质量,具有较高安全性。

Objective To observe the clinical efficacy of acupuncture-moxibustion plus Chinese medication in treating malignant ascites in ovarian cancer and its effects on ascites and Karnofsky Performance Score(KPS).Method Sixty-two patients with malignant ascites due to ovarian cancer were recruited and divided into an observation group and a control group using the random number table method,with 31 cases in each group.The patients all received intraperitoneal perfusion chemotherapy.In addition,the control group was treated with Chinse medication(Liu Wei Di Huang Wan+Liu Jun Zi Tang+modified Ji Jiao Li Huang Wan),while the observation group was given additional acupuncture-moxibustion treatment,both for 1 month.The clinical efficacy,number of times of ascites drainage,change in KPS and the incidence of adverse reactions in the two groups were compared and analyzed.Result The total effective rate in the observation group was higher than that in the control group(P<0.05).The number of times of ascites drainage in the observation group was lower than that in the control group,with statistical significance(P<0.05).Prior to treatment,there was no significant difference in the overall clinical symptoms score between the two groups(P>0.05);the overall clinical symptoms score dropped after treatment in both groups(P<0.05)and was lower in the observation group than in the control group(P<0.05).There was no significant difference in the KPS between the two groups before treatment(P>0.05);the KPS increased after treatment in both groups(P<0.05)and was higher in the observation group than in the control group(P<0.05);the incidence of adverse reactions was lower in the observation group than in the control group(P<0.05).Conclusion Acupuncture-moxibustion plus Chinese medication can produce significant efficacy in treatment of malignant ascites induced by ovarian cancer.It can improve the patients’clinical symptoms,reduce the number of times of ascites drainage,enhance the quality of life,with relatively high security evaluation.