CD4^+T淋巴细胞亚群在过敏性紫癜发病机制中的研究进展

Research Progress of CD4^+T Lymphocyte Subsets in Pathogenesis of Henoeh-Sch nlein Purpura

过敏性紫癜(HSP)是儿童时期常见的白细胞碎裂性血管炎,临床特点为不伴有血小板减少的皮肤紫癜样改变,同时会累及多个脏器(如胃肠道、关节以及肾脏)。目前HSP确切的发病机制尚未完全明确,多数研究显示与自身免疫紊乱密切相关,但具体作用机制仍不清楚。根据分泌细胞因子的不同,CD4^+T淋巴细胞可分为辅助性T细胞(Th)1、Th2、Th17和调节性T细胞4个亚群,在炎症性疾病及自身免疫性疾病中发挥着至关重要的作用。

Henoeh-Sch nlein purpura(HSP)is a common leukocytoclastic vasculitis in childhood.It is characterized by skin purpura changes without thrombocytopenia and involves multiple organs(such as gastrointestinal tract,joints and kidneys).At present,the exact pathogenesis of HSP is not completely clear,and most studies show that it is closely related to autoimmune disorders,but the specific mechanism of action is still unclear.According to the secreted cytokines,CD4^+T lymphocytes can be divided into four subsets:helper T cells(Th)1,Th2,Th17 and regulatory T cells,which play a crucial role in inflammatory diseases and autoimmune diseases.