可乐代替饮用水对小鼠健康的影响

Effects of Cola as the Only Drinking Liquid on Mice Health

可乐是一种高糖碳酸饮料,学者们普遍认为过量饮用可乐会影响机体糖脂代谢,诱发肥胖,但缺乏实验证据。该研究以6周龄雄性C57BL/6J小鼠为研究对象,以可乐代替饮用水饲养小鼠3个月,旨在确定可乐对小鼠体质量、糖脂代谢和行为的影响。结果表明,与饮用水组小鼠相比,可乐组小鼠采食量显著减少,体质量、脂肪和肝脏的质量均显著下降。通过对脂肪组织基因表达情况进行分析发现,可乐组小鼠的脂合成基因(FAS、PPARγ、aP2)、脂分解基因(ATGL、LPL、HSL)的表达水平均显著升高。行为学分析结果表明,可乐组小鼠在旷场实验中表现出更高的活跃度,在强迫游泳和悬尾实验中更容易放弃挣扎。综上所述,可乐代替饮用水会抑制小鼠食欲,减少体质量和脂肪的累积,且能够增加其活跃度。

Cola is a kind of carbonated drink with a high content of sugar,which affects glycolipid metabolism if drinking excessively.Thus,Cola is generally believed to be a factor of inducing obesity,but this opinion lacks of experimental evidence.In this study,in order to determine the effects of Cola on body weight,glycolipid metabolism and behavior of mice,6-week-old male C57BL/6J mice were fed with Cola as the only drinking liquid for three months.The results showed the food intake,body weight,fat weight and liver weight of the mice in the Cola-drinking group significantly decreased compared with those of the mice in the water-drinking group.Gene expression analysis revealed that both adipogenesis genes(FAS,PPARγ,aP2)and lipolytic genes(ATGL,LPL,HSL)in adipose tissues were up-regulated in the Cola-drinking group.In the behavioral analysis,Cola-drinking mice showed higher activity in open field experiments,and were more likely to give up struggling in forced swimming and tail suspension experiments.In summary,Cola as the only drinking liquid suppresses mice appetite,reduces body weight and fat accumulation,but increases their activity.