SEDS蛋白的结构与功能研究进展

Research Progress in the Structure and Function of SEDS Protein

肽聚糖是细菌细胞壁的主要成分,在维持细胞活性、形状和保护渗透压等方面起着重要作用。SEDS(shape,elongation,division,and sporulation)蛋白是参与肽聚糖合成的一类膜蛋白家族,其成员与细胞形状、伸长、分裂和孢子形成有关。一系列遗传和生化证据表明,SEDS蛋白具有糖基转移酶功能,是细胞延长和分裂机制的核心聚合酶。SEDS蛋白分布的广泛性、结构的保守性和功能的重要性,使其有望成为新一代抗生素研究的重要靶标。该文对SEDS蛋白的结构和功能进行了综述,重点介绍了SEDS蛋白的结构及其参与肽聚糖合成的调控机制,并对SEDS蛋白的应用和前景进行了展望。

Peptidoglycan is the main component of bacterial cell wall and plays an important role in maintaining cell viability,shape and protecting osmotic pressure.SEDS protein is a family of membrane proteins involved in peptidoglycan synthesis.Its members are related to cell shape,elongation,division and spore formation.A series of genetic and biochemical evidences show that SEDS protein has glycosyltransferase function and is the core polymerase of cell elongation and division mechanism.Considering its extensive distribution,conservative structure and critical function,SEDS protein is expected to be an essential target for the development of new antibiotics.The structure and function of SEDS protein are summarized.Its structure characteristics and regulation mechanism in peptidoglycan synthesis are highlighted.In the end,the application and development of SEDS protein are prospected.