冠状动脉钙化病变与冠状动脉介入术后对比剂肾病相关性的研究

Association of coronary artery calcification with contrast-induced nephropathy after percutaneous coronary intervention

目的:探讨冠状动脉钙化病变与冠状动脉介入治疗(PCI)后患者发生对比剂肾病(CIN)的关系。方法:随机入选2019年6月至2019年12月,于首都医科大学附属北京安贞医院接受PCI的患者200例,根据是否存在冠状动脉钙化病变分为观察组(冠状动脉存在钙化病变,n=62)即对照组(冠状动脉无钙化病变,n=138),比较两组患者临床基线资料、术前即术后36~48 h血肌酐及估算肾小球滤过率(eGFR)的水平及CIN的发生率,对冠状动脉钙化病变及PCI术后CIN发生率的关系进行分析。结果:观察组患者中12例(21.0%)发生CIN,对照组患者中14例(10.1%)发生CIN,观察组CIN发生率较对照组明显升高(P=0.046)。二元Logistic回归结果表明冠状动脉钙化病变是PCI术后患者发生CIN的危险因素(OR=1.046,95%CI:0.307~3.565,P=0.042)。结论:冠状动脉钙化病变患者PCI术后CIN发生率升高。

Objective:To investigate the relationship between coronary artery calcification and contrast-induced nephropathy(CIN)in patients underwent percutaneous coronary intervention(PCI).Methods:Patients underwent PCI(n=200)from June 2019 to December 2019 in Beijing Anzhen Hospital,Capital Medical University were selected and divided into observation group(with coronary artery calcification,n=62)and control group(without coronary artery calcification,n=138).General information,creatinine and estimated glomerular filtration rate(eGFR)before and 36-48 hours after PCI,incidence of CIN were compared between two groups.Binary Logistic regression were performed to analyze relationship between coronary artery calcification and CIN.Results:Incidence of CIN was 21.0%in observation group vs 10.1%in control group(P=0.046).Binary Logistic regression shows that coronary artery calcification is an independent risk factor of CIN after PCI(OR=1.046,95%CI:0.307-3.565,P=0.042).Conclusions:Patients with coronary artery calcification has higher incidence of CIN after PCI.