摘要
目的研究康柏西普联合曲安奈德对糖尿病性黄斑水肿(DME)患者的血管内皮生长因子(VEGF)、基质细胞衍生囚子-1(SDF-1)和视功能的影响。方法按照随机数字表法将纳入患者分为对照组47例和试验组45例。对照组,取0.5%丙美卡因滴眼液表层麻醉,玻璃体腔内注射曲安奈德0.1 mL;在对照组基础上,试验组每次于玻璃体腔内注射康柏西普50μL,每月1次,持续3次。比较2组的临床疗效、VEGF与SDF-1水平、视功能和药物不良反应(ADR)发生情况。结果治疗后,试验组和对照组总有效率分别为78.72%(37例次/47例次)和95.56%(43例次/45例次);这2组的VEGF分别为(145.11±16.91)和(187.59±24.22)pg·mL^-1;这2组的SDF-1分别为(491.95±56.42)和(561.51±69.33)mg·L^-1;这2组的最佳矫正视力分别为0.55±0.11和0.44±0.08;这2组的黄斑中央凹视网膜厚度分别为(275.56±31.06)和(337.51±37.92)μm;这2组的平均黄斑容积分别为(7.48±0.89)和(8.35±1.15)mm^-3。上述指标:2组间比较差异均有统计学意义(均P<0.05)。2组ADR以一过性高眼压为主,试验组和对照组的发生率分别为2.22%和4.26%,组间比较差异无统计学意义(P>0.05)。结论康柏西普联合曲安奈德可提高DME的疗效,降低VEGF和SDF-1水平,改善视功能。
Objective To study on the effects of Conbercept Ophthalmic Injection(COI)combined with Triamcinolone Acetonide Injection(TAI)on vascular endothelial growth factor(VEGF),stromal cell derived prisoner-1(SDF-1)and visual function of diabetic macular edema(DME).Methods DME patients were divided into two groups:47 in control groups and 45 treatment groups by simple random number method.The control group was treated with 0.1 mL TAI each time,intravitreal injection was performed and topical anesthesia with 0.5%promecaine eye drops.The treatment group was treated with 50μL of COI on the basis of the control group,and injected into vitreous cavity once a month for 3 times.The clinical efficacy,VEGF,SDF-1,visual function and adverse drugs reaction(ADR)before and after treatment were compared between the two groups.Results After treatment,the total effective rates of the treatment group and the control group were 78.72%(37 cases/47 cases)and 95.56%(43 cases/45 cases);VEGF in the two groups were(145.1116.91)and(187.59±24.22)pg·mL^-1;SDF-1 in the two groups were(491.95±56.42)and(561.51±69.33)mg·L^-1;the best corrected visual acuity of the two groups were 0.55±0.11 and 0.44±0.08;the retinal thickness of fovea fovea in the two groups were(275.56±31.06)and(337.51±37.92)μm;the average macular volume in the two groups were(7.48±0.89)and(8.35±1.15)mm-3.The differences of the indicators between the two groups were statistically significant(all P<0.05).Transient ocular hypertension was the main complication in the two groups.The incidence of ADR in treatment group and control group were 2.22%and 4.26%,there was no significant difference between the two groups(P>0.05).Conclusion COI combined with TAI can improve the curative effect of DME,reduce the level of VEGF and SDF-1,and improve visual function.
作者
周莉
刘荣
韦晓丹
田斌
吉媛红
ZHOU Li;LIU Rong;WEI Xiao-dan;TIAN Bin;JI Yuan-hong(Department of Ophthalmology,Tangshan Workers Hospital,Tangshan 063000,Hebei Province,Chirm)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2020年第13期1797-1800,共4页
The Chinese Journal of Clinical Pharmacology
基金
河北省医学研究重点课题计划基金资助项目(ZD20171384)。
关键词
康柏西普
曲安奈德
糖尿病性黄斑水肿
血管内皮生长因子
基质细胞衍生囚子-1
视功能
Conbercept Ophthalmic Injection
Triamcinolone Acetonide Injection
diabetic macular edema
vascular endothelial growth factor
stromal cell derived prisoner-1
visual function