生长因子在组织工程气管临床移植中的应用与展望

Application and prospect of growth factors in clinical transplantation of tissue engineering trachea

组织工程技术为气管重建外科提供了有效治疗手段,而如何实现移植气管的上皮细胞再生、软骨细胞再生以及血管新生是维持气道功能、保障气管移植物长期存活的关键所在。生长因子是一类通过对细胞的增殖、迁移、分化提供生物化学诱导从而指导细胞发展的信号分子,在组织工程气管再生过程中扮演着重要角色。如何设计一种能够为生长因子提供最佳活性、稳定性和可调节性的呈递系统尤为重要。本研究旨在综述应用于组织工程气管领域的生长因子的类型、特征、功能以及生长因子在组织工程气管体内原位移植中应用价值,以促进组织工程气管原位移植早日实现临床转化。

Tissue engineering provides an effective treatment for tracheal reconstruction.The key to maintain airway function and ensure long-term survival of tracheal grafts is how to achieve epithelial cell regeneration,chondrocyte regeneration,and angiogenesis of the transplanted trachea.Growth factors are signaling molecules that direct cell development by providing biochemical cues for stem cell proliferation,migration,and differentiation.They play an important role in tissue engineering trachea regeneration.It is particularly important to design a delivery system that provides optimal activity,stability and adjustability for growth factors.This article summarizes the types,characteristics,functions of growth factors applied in the field of tissue engineering trachea,and the value of gr nwth factors in tissue engineering trachea orthotopic transplantation aimed for promoting clinical transformation of tissue engineered trachea.