慢性肾脏病患者血清同型半胱氨酸与动脉粥样硬化的关系

THE RELATIONSHIP BETWEEN SERUM HCY AND ARTERIOSCLEROSIS IN CKD PATIENTS

目的探讨CKD患者血清Hcy与动脉内皮损伤的关系。方法选择80例CKD患者,其中2~4期患者为A组,已行血液透析的5期患者40例为B组;另选正常健康人40例为C组。检测各组血清Hcy及各项生化指标水平,应用超声检测左前臂桡动脉内-中膜厚度。结果三组各指标比较均有统计学意义(F=31.69~1222.20,P<0.01);两两比较显示:各指标均以B组最高,A组次之,C组最低(P<0.05)。结论CKD患者血清Hcy水平与动脉粥样硬化密切相关。

Objective To explore the relationship between serum Hcy and arterial endothelial injury in patients with CKD.Methods Eighty patients with CKD were selected.Among them,patients with stage 2 to 4 were in group A,40 patients with hemodialysis in stage 5 were in group B,and 40 healthy patients were selected as group C.Serum Hcy and various biochemical indexes were detected in each group,and the thickness of the left forearm radial artery intima-media was measured by ultrasound.Results The comparison of each index in the three groups was statistically significant(F=31.69~1222.20,P<0.01).Pairwise comparison showed that each index was the highest in group B,followed by group A,and the lowest was in group C(P<0.05).Conclusion The serum Hcy level in patients with CKD is closely related to atherosclerosis.