阿托伐他汀对脑血管介入治疗后造影剂诱导肾病的预防

ATORVASTATIN PREVENTS CIN AFTER CEREBROVASCULAR INTERVENTION

目的探究预防脑血管介入治疗后CIN的方法。方法选取100例缺血性脑血管病患者,将其随机分为对照组和观察组,各50例。介入治疗前3 d,对照组给予阿托伐他汀20 mg/d,观察组给予阿托伐他汀40 mg/d。比较两组CINd发生率,SCr、BUN、Cys-C、hsCRP、IL-6、NOS、SOD、TC、TG、LDL、HDL、AST及ALT的变化。结果介入治疗后72 h内,观察组CIN的发生率、SCr、BUN、Cys-C、hsCRP、IL-6水平明显低于对照组,NOS、SOD水平明显高于对照组(P<0.05);两组TC、TG、LDL、HDL均有所降低,AST及ALT均有升高,但两组变化幅度没有统计学意义(P>0.05)。结论高剂量阿托伐他汀可降低CIN的发生。

Objective To explore ways to prevent CIN after cerebrovascular interventional therapy.Methods 100 patients with ischemic cerebrovascular disease were randomly divided into a control group and an observation group,50 cases each.Three days before the interventional treatment,the control group was given atorvastatin 20 mg/d,and the observation group was given atorvastatin 40 mg/d.The incidence of CINd,SCr,BUN,Cys-C,hsCRP,IL-6,NOS,SOD,TC,TG,LDL,HDL,AST and ALT were compared between the two groups.Results Within 72 hours after the interventional treatment,the incidence of CIN,SCr,BUN,Cys-C,hsCRP,and IL-6 in the observation group was significantly lower than those in the control group,and the levels of NOS and SOD were significantly higher than that in the control group(P<0.05).TC,TG,LDL,and HDL in both groups were decreased.AST and ALT were increased,but the change range of the two groups was not statistically significant(P>0.05).Conclusion High-dose atorvastatin can reduce the occurrence of CIN.