肝移植术后感染的供体相关性危险因素分析

Analysis of donor risk factors for post-liver transplantation infection

目的探讨公民逝世后器官捐献供肝肝移植患者感染的供体相关因素。方法回顾性分析中山市人民医院2015年1月1日—2019年12月31日100例接受公民逝世后器官捐献供肝肝移植手术患者的临床资料。根据患者术后感染情况将病例分为感染组和非感染组,对发生肝移植术后感染的供体可能相关的因素进行单因素分析,将相关因素纳入多因素Logistic回归分析,对肝移植术后感染进行预测或风险评估。结果单因素分析得出供体白/球蛋白比、供体总胆汁酸及供体白蛋白评分3个因素是器官捐献供肝肝移植术后感染的相关因素(P<0.05)。多因素Logistic回归分析结果显示,供体总胆汁酸及供体白蛋白评分为器官捐献供肝肝移植术后感染的独立相关因素(P<0.05)。结论术前低供体总胆汁酸及供体白蛋白评分,其肝移植术后感染风险较小。

Objective To investigate the donor risk factors for post-liver transplantation infection in donation after the death of citizens.Methods A retrospective analysis of the clinical data of 100 patients from January 1,2015 to December 31,2019 at Zhongshan People's Hospital was performed.The patients accepted organ donation after the death of citizens for liver transplantation.The patients were divided into infection group and non-infection group according to the postoperative infection status of the patients.Univariate analysis was performed on possible factors related to donor-associated infection after liver transplantation,and related factors were included in multivariate logistic regression.Predictive or risk assessment of infection after liver transplantation were analyzed.Results The univariate analysis revealed that the donor albumin ratio,donor total bile acid and donor albumin score were related to infection after liver transplantation(P<0.05).Multivariate logistic regression analysis showed that donor total bile acid and donor albumin scores were independent related factors for infection after liver transplantation(P<0.05).Conclusion Low donor total bile acid and donor albumin scores before surgery were associated with lower risk of infection after liver transplantation.