金丝梅正丁醇部位化学成分研究

Study on the chemical constituents in N-butanol extracts from Hypericum patulum Thumb.

目的研究金丝梅(Hypericum patulum Thumb.)正丁醇部位的化学成分。方法采用系统溶剂法、柱色谱分离法对金丝梅正丁醇部位的化学成分进行分离,并鉴定化合物结构。结果从金丝梅正丁醇部位中分离得到13个化合物,分别鉴定为正三十二烷醇(1)、5-O-咖啡酰基奎宁酸丁酯(2)、1-O-咖啡酰基奎宁酸甲酯(3)、莽草酸(4)、5-O-香豆酰基奎宁酸甲酯(5)、quercetin-3-O-(4″-methoxy)-α-L-rahmnopyranosyl(6)、槲皮素(7)、槲皮素-3-O-α-L-鼠李糖苷(8)、大叶菜酸(9)、大叶菜酸甲酯(10)、5-O-咖啡酰基奎宁酸甲酯(11)、金丝桃苷(12)和芦丁(13)。结论化合物1~6、9、10、12、13为首次从金丝梅中分离得到。

Objective To investigate the chemical constituents in N-butanol extracts from Hypericum patulum Thumb..Methods The chemical constituents of N-butanol extracts were separated by the method of systematic solvent and column chromatography,and the structure of the resultant compounds was identified.Results Thirteen compounds were obtained and identified as 1-dotriacontanol(1),5-O-cafffeoyl quinic acid butyl ester(2),1-O-caffeoyl quinic acid methyl ester(3),shikimic acid(4),5-O-coumaroyl quinic acid methyl ester(5),quercetin-3-O-(4″-methoxy)-α-L-rahmnopyranosyl(6),quercetin(7),quercetin-3-O-α-L-rhamnoside(8),doederleninic acid(9),methyl doederleninic acid(10),5-O-caffeoyl quinic butyl acid ester(11),hyperoside(12)and rutin(13).Conclusions Compounds 1-6,9,10,12,13 are isolated for the first time from Hypericum patulum Thumb.