盐酸度洛西汀治疗膀胱过度活动综合征合并焦虑抑郁共病的随机对照研究

Clinical randomized controlled study of duloxetine in the treatment of overactive bladder syndrome with anxiety and depression

目的观察盐酸度洛西汀治疗膀胱过度活动综合征(overactive bladder syndrome,OAB)合并焦虑抑郁共病的临床疗效。方法采用随机对照设计,将膀胱过度活动综合征合并焦虑抑郁共病患者分为药物组和对照组,每组40例。两组患者均给予综合治疗,同时药物组加用盐酸度洛西汀治疗,对照组加用琥珀酸索利那新片治疗。治疗前及治疗第12周时采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、症状自评量表(SCL-90)、国际前列腺症状评分(IPSS)及生活质量指数评分(QOL)评价两组OAB患者临床症状、情绪状态及生活质量。结果治疗前,两组患者IPSS评分、HAMA总分、躯体化焦虑及精神化焦虑分值、HAMD总分、焦虑/躯体化及睡眠障碍等因子分值组间差异无统计学意义(P>0.05);治疗12周后,药物组患者IPSS评分、SCL-90总分及躯体化、强迫状态、焦虑和抑郁等因子分值下降明显,与对照组比较差异有统计学意义(P<0.05);同时药物组患者QOL评分较对照组明显下降,差异有统计学意义(P<0.05)。结论盐酸度洛西汀治疗可显著改善OAB及焦虑抑郁症状。

Objective To observe the clinical efficacy of duloxetine in the treatment of overactive bladder syndrome with anxiety and depression.Methods The randomized control study was designed 80 overactive bladder syndrome with anxiety and depression patients were randomly assigned to groups drug and control.Each group has40 cases.All the two groups were treated with integrated treatments.Besides Duloxetine was added to drug group,Vesicare(Solifenacin Succinate Tablets) was added to control group.Before the treatment and at the 12 th week of treatment,HAMA,HAMD,SCL-90,IPSS and QOL were used to evaluate two groups of OAB patient s clinical symptoms,emotional state and quality of life.Results Before treatment,there was no significant difference in the scores of IPSS,HAMA,somatization anxiety and spiritual anxiety,HAMD,anxiety/somatization and sleep disorder between the two groups(P> 0.05);after 12 weeks of treatment,the scores of IPSS,SC L-90 and somatization,obsessive state,anxiety and depression in the drug group were significantly lower than those in the control group(P <0.05);and the QOL score in the drug group was significantly lower than that in the control group(P <0.05).Conclusion Duloxetine is effective in the treatment of overactive bladder syndrome with anxiety and depression.