肠息肉病因学相关性研究进展

Research Progress in Etiological Correlation of Intestinal Polyps

近年来,结直肠癌已成为世界上继肺癌、乳腺癌之后的第三大常见恶性肿瘤,其中90%来自肠腺瘤。为降低结直肠癌的发病率和病死率,肠息肉的病因病机受到密切关注。肠息肉是临床上的常见病变,无特异性临床表现,但具有高发率及恶变潜力,且病因尚未明确,故探索有效的预防手段成为关键。随着预防医学和精准医学等研究的深入,患病人群的饮食习惯、血脂、尿酸、血压、血糖、幽门螺杆菌、胆囊疾病、肠道菌群等因素的影响日益凸显,其作用方向和机制探讨均取得了新的进展。

In recent years,colorectal cancer has become the third most common malignant tumor in the world after lung and breast cancer,90%of which comes from intestinal adenoma.In order to reduce the incidence and mortality of colorectal cancer,close attention has been paid to the etiology and pathogenesis of intestinal polyps.Intestinal polyp is a common clinical lesion with no specific clinical manifestations,but it has a high incidence and canceration potential with unclear etiology,so it is the key to explore effective preventive measures.With the deepening of preventive medicine and precision medicine,the influence of eating habits,blood lipids,uric acid,blood pressure,blood glucose,Helicobacter pylori,gallbladder disease,intestinal flora and other factors has become increasingly prominent,and new progress has been made in the discussion of its action direction and mechanism.