趋化因子与子宫内膜异位症的关系研究进展

Research Progress in Relationship between Chemokines and Endometriosis

趋化因子是一类小分子可溶性蛋白质,生物学活性广泛,与机体的多种生理及病理过程相关。子宫内膜异位症(EMT)是一种常见妇科慢性炎症性疾病,严重影响患者的生活质量和身心健康,其病因及具体发病机制至今尚未阐明,可能与机体免疫调节异常及慢性炎症相关。近年来发现,趋化因子及其受体通过促进异位内膜细胞增殖、黏附、粘连以及促进异位灶血管生成参与EMT的发生、发展,此外,与EMT相关的趋化因子也有望成为未来筛查、诊断及监测EMT的重要指标。

Chemokine is a kind of small and soluble protein,which has a wide range of biological activities and is related to a variety of physiological and pathological processes.Endometriosis(EMT)is a common chronic inflammatory disease of gynecology,which seriously affects the quality of life and the mental health of the patients.Its etiology and specific pathogenesis have not been clarified yet,which may be related to abnormal immune regulation and chronic inflammation of the body.In recent years,it has been discovered that chemokines and their receptors are involved in the occurrence and development of EMT by promoting the proliferation and adhesion of ectopic endometrial cells,and promoting the angiogenesis of ectopic foci.In addition,chemokines associated with EMT are also expected to become the important indicators for screening,diagnosis and monitoring of EMT in the future.