有机磷腈碱催化环内酯开环聚合制备可降解聚酯研究进展

Ring-opening Polymerization of Cyclic Esters by Utilizing Organophosphazene Bases toward Biodegradable Polyesters

脂肪族聚酯作为一类重要的高分子材料,具有优异的生物相容性和生物可降解性以及良好的力学性能,在可吸收手术缝合线、组织工程支架、食品包装等方面已经取得了广泛应用.环内酯开环聚合是制备脂肪族聚酯材料的一种重要方法.有机磷腈碱作为一类非离子型、非亲核性有机强碱,在催化环内酯开环聚合方面已经取得了巨大的成功.本专论综述了有机磷腈碱在催化γ-丁内酯及其衍生物、己内酯、戊内酯、丙交酯和大环内酯开环聚合方面的研究进展,对聚合机理进行了适当讨论,并对其未来发展方向作了展望.

Given their great biocompatibility, biodegradability and good mechanical properties, aliphatic polyesters as important polymers have been widely used in many applications as absorbable sutures, tissue engineering scaffolds and food packing materials. Aliphatic polyesters can be synthesized by ring-opening polymerization(ROP) of cyclic lactones or lactides. Organophosphazene bases are a family of uncharged, nonnucleophilic organobases, which have achieved great success as organocatalysts for the ROP of cyclic lactones and lactides. This feature article reviewed the recent progresses for ROP of cyclic lactones and lactides by utilizing phosphazene bases as catalysts, including γ-butyrolactone and its derivatives, ε-carprolactone, δ-valerolactone,lactide and macrolactones. The challenges and perspectives on the further development of phosphazene base catalyzed ROP were also discussed.