骨骼肌生长发育及再生过程中Wnt信号网络的作用机制

Mechanism of Wnt Signaling Network in Skeletal Muscle Growth,Development and Regeneration

Wnt信号网络是由Wnt配体介导的经典和非经典信号通路协同参与,调控机体生长发育等过程所形成的复杂信号网络。骨骼肌组织结构精密、功能复杂且具有高度可塑性,其生长发育受到多种信号通路的严格调控,其中Wnt信号网络尤为重要。前期研究表明,Wnt信号网络主要参与胚胎期骨骼肌生成和介导卫星细胞调控骨骼肌的生长发育及再生等过程。近年来,有关Wnt信号网络调控骨骼肌的研究愈加深入,探索经典和非经典Wnt信号通路之间的协同作用也成为了研究热点。本文旨在综述Wnt信号网络参与调控骨骼肌生长发育及再生过程,并对经典和非经典Wnt信号通路之间的相互作用进行探讨,期望通过Wnt信号网络对骨骼肌的生长发育及再生的调控机制,为畜牧生产及基础研究提供理论依据,从而通过营养精准调控肌肉生长及肉品质改善。

Wnt signaling network is a complex signal network formed by the canonical and noncanonical signaling pathways mediated by Wnt ligands,which regulates the growth and development of the body.Skeletal muscle tissue has a precise structure,complex functions,and high plasticity.Its growth and development are strictly regulated by a variety of signaling pathways,of which the Wnt signaling network is particularly important.Previous studies have shown that the Wnt signaling network is mainly involved in embryonic skeletal muscle generation and mediates satellite cells to regulate skeletal muscle growth,development and regeneration.In recent years,research on the regulation of skeletal muscle by Wnt signaling network has become more in-depth,and exploring the synergy between canonical and noncanonical Wnt signaling pathways has also become a research hotspot.This article aims to review the involvement of Wnt signaling network in the regulation of skeletal muscle growth,development and regeneration,and to explore the interactions between canonical and noncanonical Wnt signaling pathways.It is expected that the regulation mechanism of skeletal muscle growth,development and regeneration through the Wnt signaling network will provide theoretical basis for livestock production and basic research,so as to precisely regulate muscle growth and improve meat quality through nutrition.