肠道菌群的昼夜节律性及其与宿主间代谢互作的研究进展

Research Progress on Circadian Rhythm of Intestinal Microflora and Their Metabolic Interaction with Host Animals

肠道菌群具有24 h昼夜节律并与宿主生物钟之间存在复杂的相互作用。当肠道菌群昼夜节律紊乱,会造成体内产生一系列生理和病理的改变;而当宿主的昼夜节律破坏,还会引起肠道菌群节律发生变化。本文主要综述肠道菌群的节律特征、影响因素、肠道菌群节律与宿主生物钟的双向作用及其相互关系,以期为研究肠道菌群节律及其与宿主生物钟相互作用的代谢机理提供参考。

There is a complex interaction and balance between 24 h circadian rhythm of intestinal flora and host biological clock.When the circadian rhythm of intestinal flora is destroyed,the body will produce a series of physiology and pathology changes;when the circadian rhythm of the host is destroyed,also cause the change in the rhythm of intestinal flora.This paper mainly reviews the rhythm characteristic,influencing factors,bidirectional interaction and relationship between intestinal flora rhythm and host biological clock,in order to provide some references for the study of intestinal flora rhythm and metabolic mechanism between intestinal flora rhythm and host biological clock.