非酒精性脂肪性肝病发病机制研究

Study on the pathogenesis of non-alcoholic fatty liver disease

随着生活水平的提高及不良生活习惯的养成,非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)的发病率已跃居肝病领域的首位,疾病谱包括NAFLD、非酒精性脂肪性肝炎(non-alcoholic steatohepatitis, NASH)、肝纤维化、肝硬化甚至肝癌。虽然目前有许多关于NAFLD的研究,但其发病机制尚不明确,本文就近年NAFLD发病机制方面的研究作一概述,为NAFLD的治疗和预防指引方向。

With the improvement of living standard and the formation of bad living habits, the incidence of non-alcoholic fatty liver disease(NAFLD) has become the first in the field of liver disease.Disease spectrum includes NAFLD, non-alcoholic steatohepatitis(NASH), liver fibrosis, liver cirrhosis, even liver cancer. Although there have been many studies on NAFLD, the pathogenesis of NAFLD is still unclear. In this paper, studies on the pathogenesis of NAFLD in recent years are summarized to provide guidance for the treatment and prevention of NAFLD.