消化疾病的口腔菌群基础及在诊断中的应用

The oral microbiome basis and its application in diagnosis of digestive diseases

随着近年来对人体微生物的研究不断深入,疾病与微生物变化的特征性联系逐渐明确。消化道是微生物的主要生存场所,微生物的变化在消化疾病的发生、发展中起着尤为关键的作用。口腔作为消化道的第一道关口,微生物基数庞大,且种类、丰度、数量的变化易于检测。口腔菌群检测,可以为消化疾病的诊断提供新的方向,并为中医舌诊的微生物学基础提供依据。本文概述了口腔菌群在不同消化疾病中的变化及意义,并对口腔菌群研究中的难点和发展方向进行了总结。

With the develop of research on human microorganisms in recent years, the characteristic connection between diseases and microbial changes was gradually clear. The digestive tract was the main living environment of microorganisms, and the changes of microorganisms play a key role in the occurrence and development of digestive diseases. As the first pass of digestive tract, oral cavity had a large number of microorganisms, the variety, abundance and quantity were easy to detect. By detecting the oral microbiome, that could provide a new direction for the diagnosis of digestive diseases and a biological basis for tongue diagnosis in traditional Chinese medicine. This paper reviewed the significance and varieties of oral microbiome in different digestive diseases. Meanwhile, the challenges and future directions in the research of oral microbiome were also summarized.