外泌体参与肝脏疾病的研究进展

Advances in research on exosomes involvement in liver diseases

外泌体是细胞分泌含有蛋白质、脂质、核酸和膜受体的纳米级囊泡,介导细胞间的信号传导和物质转运,涉及多种疾病的发病机理。研究发现,其在多种肝脏疾病中发挥重要的作用,如肝细胞癌、病毒性肝炎、肝纤维化、酒精性和非酒精性脂肪性肝病、肝衰竭等。外泌体在各类肝脏病症的诊断、治疗及预后中具有重要价值,同时也是肝病新的潜在治疗手段和治疗靶点。本文就外泌体在肝脏疾病中的作用及其对肝脏疾病潜在的诊治价值进行归纳,为从外泌体角度认识肝脏疾病发生与发展及其临床防治提供新的思路。

Exosomes are cells that secrete nano-sized vesicles containing proteins, lipids, nucleic acids and membrane receptors, which mediate signal transduction and substance transport between cells, and are involved in the pathogenesis of various diseases. The study found that it plays an important role in a variety of liver diseases, such as hepatocellular carcinoma, viral hepatitis, liver fibrosis, alcoholic and non-alcoholic fatty liver disease, liver failure and other liver diseases. Exosomes are of great value in the diagnosis, treatment and prognosis of various liver diseases, and are also new potential therapeutic and therapeutic targets for liver diseases. This article summarizes the role of exosomes in liver diseases and its potential diagnosis and treatment of liver diseases, and provides new ideas for understanding the occurrence and development of liver diseases and its clinical prevention from the perspective of exosomes.