微柱凝胶法交叉配血检测联合微柱凝胶法不规则抗体筛查对临床输血安全的影响

Effect of microcolumn gel(MGT)cross matching blood test combined with MGT irregular antibody screening on the safety of clinical transfusion

目的分析微柱凝胶法(MGT)交叉配血检测联合MGT不规则抗体筛查对临床输血安全的影响。方法随机选取中国人民解放军联勤保障部队第989医院2017年1月至2018年12月收治100例住院需输血的患者作为研究对象,采用双盲法将其分成对照组及观察组,每组50例患者。对照组接受微柱凝胶法(MGT)交叉配血检测,观察组患者接受微柱凝胶法(MGT)交叉配血检测联合MGT不规则抗体筛查。比较两组交叉配血结果、阳性、阴性检测结果、临床输血安全。结果观察组患者主侧凝集率、次侧凝集率、主次侧均凝集率高于对照组,但差异未见统计学意义(P>0.05)。观察组患者阴性率低于对照组(P<0.05),阳性率高于对照组(P<0.05)。观察组患者抗-E、抗-EC率高于对照组(P<0.05),抗-c率高于对照组,但差异未见统计学意义(P>0.05)。观察组临床输血安全性高于对照组(P<0.05)。结论微柱凝胶法(MGT)交叉配血检测联合MGT不规则抗体筛查能提高验血阳性率,提升临床输血安全,建议使用。

Objective To analyze the effect of microcolumn gel(MGT)cross matching blood test combined with MGT irregular antibody screening on the safety of clinical transfusion.Methods A total of 100 patients who needed blood transfusion in the 989 th Hospital of the Joint Service Support Force of the Chinese People’s Liberation Army from January 2017 to December 2018 were randomly selected as the study objects.They were divided into control group and observation group by double-blind method,with 50 patients in each group.The control group received microcolumn gel(MGT)cross matching test.The observation group received microcolumn gel(MGT)cross matching test and MGT irregular antibody screening.The results of cross matching,positive and negative tests,and clinical transfusion safety were compared between the two groups.Results The main side agglutination rate,the secondary side agglutination rate and the primary and secondary side agglutination rate in the observation group were higher than those in the control group,but there was no significant difference(P>0.05).The negative rate of the observation group was lower than that of the control group(P<0.05),and the positive rate was higher than that of the control group(P<0.05).The rate of anti-E and anti-EC in the observation group was higher than that in the control group(P<0.05),and the rate of anti-C was higher than that in the control group,but there was no significant difference(P>0.05).The safety of blood transfusion in the observation group was higher than that in the control group(P<0.05).Conclusions Microcolumn gel method(MGT)cross matching blood test combined with MGT irregular antibody screening can improve the positive rate of blood test and enhance the safety of clinical transfusion.