SLC6A4甲基化与精神心理疾病易感性和冠心病预后的关系

The association of SLC6A4 methylation,susceptibility to psychosomatic disease and prognosis of coronary heart disease

随着社会发展,慢性社会心理压力导致的心身疾病已成为威胁人们健康的重要因素。研究发现多种基因的表观修饰和心身疾病发生发展密切相关,其中五羟色胺转运体基因甲基化作用的研究开展广泛,但各研究结果间却相互矛盾。已知倦怠与五羟色胺转运体基因甲基化有关,又是冠心病预后的重要影响因素。本文主要对五羟色胺转运体基因甲基化与精神心理疾病易感性的关系进行阐述,并提出其作为冠心病预后预测指标的可能性。

Psychosomatic disease has become an important threat to our health with the development of society.And some epigenetic modifications in various genes have been found linked to these diseases.Especially for the SLC6 A4 methylation,many studies have been conducted,but the outcomes remained controversial.Burnout,one important factor of the prognosis of coronary heart disease,its association with SLC6 A4 methylation has been widely accepted.This review mainly described recent studies on the links between SLC6 A4 methylation and susceptibility to psychosomatic disease,then raised a hypothesis that whether it could be a biomarker of the prognosis of coronary heart disease.