低分子肝素与大剂量尿激酶溶栓治疗急性脑梗死的效果比较

Comparison of effects of low molecular weigh heparin versus high dose urokinase thrombolysis on patients with acute cerebral infarction

目的:比较低分子肝素与大剂量尿激酶溶栓治疗急性脑梗死的临床效果。方法:抽取2016年11月至2018年12月晋煤集团总医院收治的急性脑梗死患者80例,依据随机数字表分为观察组与对照组,每组40例。对照组采用低分子肝素治疗,观察组则应用大剂量尿激酶溶栓,比较两组总有效率、治疗期间并发症、美国国立卫生院卒中量表(NHISS)评分、日常活动能力(ADL)量表评分。结果:观察组总有效率高于对照组(97.50%比80.00%),治疗期间并发症发生率低于对照组(5.00%比22.50%),差异有统计学意义(P<0.05)。治疗结束时,观察组NHISS评分为(8.16±2.81)分,低于对照组的(13.80±2.94)分,观察组ADL评分为(76.65±12.81)分,高于对照组的(68.14±12.74)分,差异有统计学意义(P<0.05)。结论:大剂量尿激酶溶栓治疗急性脑梗死并发症少,能明显缓解神经功能损害,改善患者生活质量。

Objective To compare the effects of low molecular weigh heparin and high dose urokinase thrombolysis on patients with acute cerebral infarction.Methods A total of 80 patients with acute cerebral infarction who received treatment in Jinmei Group General Hospital from November 2016 to December 2018 were selected and divided into observation group and control group according to the random number table,with 40 cases in each group.The control group was treated with low molecular weight heparin,while the observation group was treated with high-dose urokinase thrombolysis.The total effective rate after treatment,the complications during treatment,the National Institute of Health Stroke Scale(NHISS)score,the activity of daily living scale(ADL)score were compared between the two groups.Results Compared with the control group,the total effective rate after treatment in the observation group was higher(97.50%vs.80.00%),and the incidence of complications during treatment was lower(5.00%vs.22.50%),the differences were statistically significant(P<0.05).At the end of treatment,the NHISS score in the observation group was(8.16±2.81)points,which was lower than(13.80±2.94)points of the control group,and the ADL score in the observation group was(76.65±12.81)points,which was higher than(68.14±12.74)points of the control group,the differences were statistically significant(P<0.05).Conclusions High dose urokinase thrombolysis has fewer complications in the treatment of acute cerebral infarction,which can significantly alleviate neurological impairment,improve patients’quality of life.