摘要
miRNA是一类非编码RNA,在细胞增殖、凋亡以及分化过程中扮演着十分重要的角色。其中miRNA-381(hsa-miR-381)是近年来新鉴定的出的一种miRNA,miR-381的编码基因位于14号染色体的长臂上,属于miR-154基因家,最早发现于胃癌。有研究表明,miR-381在肺癌、肝癌、结肠癌和骨肉瘤等恶性肿瘤中异常表达,提示其在肿瘤的发生和进展中起重要作用。本文就miR-381与恶性肿瘤的相关研究进展作一综述。
miRNA is a kind of noncoding RNA,which plays a very important role in cell proliferation,apoptosis and differentiation.The miRNA-381(hsa-miR-381)is a kind of new micrornas which is identified in recent years.The encoded gene,originally found in the stomach,which belongs to the miR-154 gene family,is on the long arm of chromosome 14.Several studies have shown that miR-381 has abnormal expression in lung cancer,liver cancer,colon cancer,malignant tumors and other osteosarcoma,which plays an important role in the occurrence and progress of tumor.This paper summarizes the research progress of miR-381 in multiple malignant tumors.
作者
徐洁欢
向琳
李耀军
邓玉屏
XU Jie-huan;XIANG Lin;LI Yao-jun;DENG Yu-ping(School of Nursing,Changsha Health Vocational College,Hu′nan Province,Changsha 410600,China;The Fifth Department of Gynecoma,the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Hu′nan Province,Changsha 410013,China)
出处
《中国当代医药》
2020年第21期22-25,共4页
China Modern Medicine
基金
湖南省教育厅科学研究项目(18C1856)
湖南省长沙市科技局项目(ZD1801008)
湖南省普通高校青年骨干教师培养项目。